Zhi Bai Di Huang Wan - 知柏地黄丸 - Anemarrhen Rehmannia Eight Formula (Granules)

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What is Zhi Bai Di Huang Wan?

Zhi Bai Di Huang Wan is a traditional Chinese medicine developed by Zhu Dan-Xi, a renowned physician of the Yuan dynasty, in the 14th century. A modification of Liu Wei Di Huang Wan, this formula is comprised of two additional herbs – Huang Bai and Zhi Mu – to clear fire, drain dampness and enrich yin.

Zhi Bai Di Huang Wan is also known as Zhi Bo Di Huang Wan, or Anemarrhen Rehmannia Eight Formula.

What are the benefits of Zhi Bai Di Huang Wan?

Zhi Bai Di Huang Wan is best known as the formula for “Steaming Bone Syndrome.” This pattern in traditional Chinese medicine (TCM) encompasses menopausal symptoms, including hot flashes, night sweats, low-grade fever, dry mouth, and tinnitus.

What is the dosage and method for taking Zhi Bai Di Huang Wan?

The generally recommended dosage of Zhi Bai Di Huang Wan is 4.5 g mixed with hot water, 2-3 times per day; or in capsule form, four capsules, two to three times daily. However, always follow your healthcare provider's instructions, as the dosage can vary based on your condition and response to treatment.

Please see What's the Recommended Dosage for Granule Herbs? for more information.

When can I expect to see results?

Zhi Bai Di Huang Wan typically starts to show effects within days. However, like all treatments, its efficacy can vary from person to person.

Does Zhi Bai Di Huang Wan have any side effects?

While Zhi Bai Di Huang Wan is generally considered safe for most people, it can cause side effects in some individuals. Women who are pregnant, nursing, or postpartum as well as people with liver disease, should avoid or use Zhi Bai Di Huang Wan with caution.

As with any Chinese herb, we recommend consulting with a qualified practitioner of traditional Chinese medicine (TCM) about Zhi Bai Di Huang Wan before any course of treatment is started. 

Where to buy Zhi Bai Di Huang Wan

For practitioners, Treasure of the East offers full-spectrum Zhi Bai Di Huang Wan capsules as well as granules in 100g bottles and bulk packaging

If you’re a consumer looking to purchase Zhi Bai Di Huang Wan, look for suppliers who provide clear information about the product's origin, purity, and testing procedures to ensure you're getting a high-quality product. Please read Where to Buy Chinese Herbs Safely for more tips on how to source herbs safely.

Zhi Bai Di Huang Wan from Treasure of the East is:
✔️ ISO Lab Tested & GMP Certified
✔️ Bio-Authentic with Full Traceability
✔️ Sustainably Sourced from Dao Di Farms

Item Number: Z030
Chinese Name: 知柏地黄丸, Zhi Bai Di Huang Wan or Zhi Bo Di Huang Wan
English Name: Anemarrhen Rehmannia Eight Formula
Functions: Enriches Yin, nourishes the essence of the liver and kidneys, reduces deficiency Fire
TCM Pattern: Kidney Yin deficiency with Fire flaring, Fire flaring with liver and kidney Yin deficiency, steaming bone disorder, Damp-Heat in the lower Jiao
Potency: Concentrated 5:1; Full-spectrum, water-based herbal extract.
Available in: capsules, 100g granules, and bulk packaging.


Shu Di Huang Rehmannia Root (Processed)
Shan Yu Rou Cornus Fruit (Processed)
Shan Yao Dioscorea Rhizome
Ze Xie Alisma Rhizome
Mu Dan Pi Moutan Bark
Zhi Mu Anemarrhena Rhizome
Huang Bo (Chuan) Phellodendron Bark
Fu Ling Poria


Treasure of the East’s herbal extracts are full-spectrum, water-based extracts produced by Tianjiang Pharmaceutical. Unlike standardized extracts, which contain a concentrated quantity of a single marker chemical, full-spectrum herbal extracts contain all the active chemical constituents of whole herbs in concentrated form.  Treasure of the East herbs are full-spectrum and extracted using only purified water (more information).

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